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- Title
Impact of Dietary Lipids on the Reverse Cholesterol Transport: What We Learned from Animal Studies.
- Authors
Papotti, Bianca; Escolà-Gil, Joan Carles; Julve, Josep; Potì, Francesco; Zanotti, Ilaria
- Abstract
Reverse cholesterol transport (RCT) is a physiological mechanism protecting cells from an excessive accumulation of cholesterol. When this process begins in vascular macrophages, it acquires antiatherogenic properties, as has been widely demonstrated in animal models. Dietary lipids, despite representing a fundamental source of energy and exerting multiple biological functions, may induce detrimental effects on cardiovascular health. In the present review we summarize the current knowledge on the mechanisms of action of the most relevant classes of dietary lipids, such as fatty acids, sterols and liposoluble vitamins, with effects on different steps of RCT. We also provide a critical analysis of data obtained from experimental models which can serve as a valuable tool to clarify the effects of dietary lipids on cardiovascular disease.
- Subjects
CHOLESTEROL content of food; HDL cholesterol; BIOLOGICAL models; FAT content of food; CARDIOVASCULAR diseases
- Publication
Nutrients, 2021, Vol 13, Issue 8, p2643
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13082643