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- Title
Dietary Copper/Zinc Ratio and Type 2 Diabetes Risk in Women: The E3N Cohort Study.
- Authors
Laouali, Nasser; MacDonald, Conor-James; Shah, Sanam; El Fatouhi, Douae; Mancini, Francesca Romana; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine
- Abstract
The serum copper (Cu) to zinc (Zn) ratio could be an important determinant of Type 2 diabetes (T2D) risk, but prospective epidemiological data are scarce. We aimed to investigate the association between T2D incidence and the dietary Cu/Zn ratio. A total of 70,991 women from the E3N cohort study were followed for 20 years. The intakes of copper and zinc were estimated at baseline using a validated food frequency questionnaire. We identified and validated 3292 incident T2D cases. Spline analysis showed that a Cu/Zn ratio < 0.55 was associated with a lower risk of T2D. Subgroup analyses comparing women in the highest versus the lowest quintile of Cu/Zn ratio showed the same pattern of association for obese women and those with zinc intake ≥8 mg/day. However, for women with zinc intake <8 mg/day, higher Cu/Zn ratio appeared to be associated with higher T2D risk. Our findings suggest that a lower dietary Cu/Zn ratio is associated with a lower T2D risk, especially among obese women and women with zinc intake >8 mg/day. Further studies are warranted to validate our results.
- Subjects
OBESITY; RESEARCH; DIET; TYPE 2 diabetes; RISK assessment; MATHEMATICAL variables; QUESTIONNAIRES; COPPER; ZINC; LONGITUDINAL method; DISEASE risk factors
- Publication
Nutrients, 2021, Vol 13, Issue 8, p2502
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13082502