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- Title
Conjugated Linoleic Acid Isomers Affect Profile of Lipid Compounds and Intensity of Their Oxidation in Heart of Rats with Chemically-Induced Mammary Tumors—Preliminary Study.
- Authors
Białek, Małgorzata; Białek, Agnieszka; Czauderna, Marian
- Abstract
Breast cancer and cardiovascular diseases (CVD) have shared risk factors and mechanisms of pathogenicity, as proven by increased cardiac risk in breast cancer patients receiving anticancerogenic therapies and in cancer survivors. A growing mammary tumor may cause heart injury in cancer patients who have not yet been treated. This study aimed to evaluate the effect of conjugated linoleic acid (CLA) supplementation of female rats with 7,12-dimethylbenz(a)anthracene (DMBA)-induced cancerogenesis on fatty acids (FAs), conjugated FAs (CFAs), malondialdehyde (MDA), cholesterol and oxysterols content in cardiac tissue. FAs, cholesterol and oxysterols contents were determined by gas chromatography coupled with mass spectrometry, while the contents of CFAs and MDA were determined by high performance liquid chromatography with photodiode detection. Our results indicate that both CLA supplementation and the presence of tumors influence the lipid biomarkers of CVD. A significant interaction of both experimental factors was observed in the content of polyunsaturated FAs (PUFAs), n-6 PUFAs and CFAs. CLA supplementation significantly inhibited PUFA oxidation, as evidenced by the lower content of MDA in rats' hearts, while the cancerous process intensified the oxidation of cholesterol, as confirmed by the elevated levels of 7-ketocholesterol in DMBA-treated rats. These results may significantly expand knowledge about CLA properties in terms of the prevention of co-existing non-communicable diseases.
- Subjects
FATTY acid analysis; ANIMAL experimentation; BREAST tumors; CARDIOVASCULAR diseases risk factors; CHOLESTEROL; DIETARY supplements; GAS chromatography; HEART; HIGH performance liquid chromatography; HYDROCARBONS; LIPIDS; MASS spectrometry; OXYSTEROLS; RATS; UNSATURATED fatty acids; LINOLEIC acid; MALONDIALDEHYDE; OXIDATIVE stress; NON-communicable diseases; DISEASE complications
- Publication
Nutrients, 2019, Vol 11, Issue 9, p2032
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11092032