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- Title
Folic Acid for the Prevention of Colorectal Adenomas.
- Authors
Cole, Bernard F.; Baron, John A.; Sandler, Robert S.; Haile, Robert W.; Ahnen, Dennis J.; Bresalier, Robert S.; McKeown-Eyssen, Gail; Summers, Robert W.; Rothstein, Richard I.; Burke, Carol A.; Snover, Dale C.; Church, Timothy R.; Allen, John I.; Robertson, Douglas J.; Beck, Gerald J.; Bond, John H.; Byers, Tim; Mandel, Jack S.; Mott, Leila A.; Pearson, Loretta H.
- Abstract
This article presents research on the use of folic acid for the prevention of colorectal adenomas. The object of the study was to assess the safety and efficacy of folic acid supplements for preventing colorectal adenomas. The study found that folic acid a 1mg/d does not reduce colorectal adenoma risk in patients with a recent history of adenomas and there was no evidence of benefit among subgroups that might be considered sensitive to the chemopreventive effects of foliate. The authors say that further research is need to investigate the possibility that folic acid supplements might increase the risk of colorectal neoplasia.
- Subjects
THERAPEUTIC use of folic acid; COLON cancer; ADENOMA prevention; DRUG efficacy; PRECANCEROUS conditions; CLINICAL trials; HEALTH outcome assessment
- Publication
JAMA: Journal of the American Medical Association, 2007, Vol 297, Issue 21, p2351
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.297.21.2351