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- Title
Is hepatitis C virus involved in hepatitis-associated aplastic anemia?
- Authors
Pol, Stanislas; Driss, Francoise; Devergie, Agnes; Brechot, Christian; Berthelot, Pierre; Gluckman, Eliane; Pol, S; Driss, F; Devergie, A; Brechot, C; Berthelot, P; Gluckman, E
- Abstract
<bold>Objective: </bold>To determine whether hepatitis C virus is involved in hepatitis-associated aplastic anemia.<bold>Design: </bold>Retrospective analysis.<bold>Setting: </bold>Bone marrow transplantation unit.<bold>Patients: </bold>One hundred and eighteen patients with severe aplastic anemia, including 19 with hepatitis-associated aplasia, 61 with aplastic anemia of undetermined cause, and 38 with aplastic anemia related to an inherited syndrome or an acquired etiology.<bold>Measurements and Main Results: </bold>There was no statistically significant difference in antihepatitis C virus antibodies between hepatitis-related aplastic anemia (15.8%; 95% CI, 4% to 36%) and aplasia of unknown (9.8%; CI, 5% to 22%) or known (7.9%; CI, 2% to 22%) cause. The antihepatitis C virus levels did not differ according to the cause of aplastic anemia. There was no relation between hepatitis C and hepatitis B virus serologies, regardless of cause.<bold>Conclusions: </bold>Hepatitis C virus is not a frequent cause of non-A, non-B hepatitis-associated aplastic anemia. Either a non-A, non-B, non-C hepatitis virus is involved in non-A, non-B hepatitis-related aplasia or hepatitis C virus prevalence is underestimated in patients with hepatitis-related aplasia, possibly as a result of immunologic defects.
- Subjects
HEPATITIS C virus; APLASTIC anemia; HEPATITIS C diagnosis; COMPARATIVE studies; EPIDEMIOLOGICAL research; HEPATITIS B; HEPATITIS C; VIRAL hepatitis; RESEARCH methodology; MEDICAL cooperation; RESEARCH; SERODIAGNOSIS; VIRAL antibodies; EVALUATION research; DISEASE prevalence; RETROSPECTIVE studies; DISEASE complications
- Publication
Annals of Internal Medicine, 1990, Vol 113, Issue 6, p435
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-113-6-435