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- Title
Methicillin, Vancomycin and Multidrug-Resistance Among Staphylococcus Aureus.
- Authors
Kulkarni, V. L.; Kulkarni, D. M.; Nilekar, S. L.; More, S. R.
- Abstract
Introduction: The difficult therapeutic problem of multidrug-resistant Staphylococcus aureus (MDRSA) is just one example of the diminishing efficacy of antimicrobial agents for the treatment of bacterial infections. The present study was undertaken to determine the prevalence of Methicillin, Vancomycin and multidrug-resistance of Staphylococcus aureus. Methodology: The study included 312 non-duplicate Staphylococcus aureus which were isolated from various clinical specimens. The isolates were tested for Methicillin resistance by Oxacillin disc diffusion, Cefoxitin disc diffusion and Oxacillin screen agar. They were also tested for vancomycin resistance by Vancomycin screen agar, agar dilution technique and E strip technique. The antibiogram was determined by Kirby Bauer Disc Diffusion Method. Results: Oxacillin screen agar technique was found to be more sensitive than Oxacillin disc diffusion method for detection of MRSA. Prevalence of MRSA in our study was found to be 36.54 %. All MRSA isolates were found to have increased resistance to all antibiotics as compared to MSSA isolates. No VISA and VRSA were found by any of the three methods. Prevalence of MDRSA in our set up was found to be 51.28%. Conclusion- In the Hospitals where resources are constrained, Cefoxitin disc diffusion method and Vancomycin screen agar can be used as screening of MRSA and VRSA strains respectively.
- Subjects
METHICILLIN-resistant staphylococcus aureus; VANCOMYCIN; BACTERIAL disease treatment
- Publication
National Journal of Integrated Research in Medicine, 2017, Vol 8, Issue 3, p68
- ISSN
2230-9969
- Publication type
Article