We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
MITIGATION OF CYTOTOXIC EFFECTS OF ENDOSULPHAN BY A-TOCOPHEROL IN KIDNEYS OF CYPRINUS CARPIO IN VITRO.
- Authors
Sharma, R. K.; Fulia, A.
- Abstract
Herbicides and pesticides are being used worldwide for protection of crops from weeds and insects in agricultural fields. Aim of the present study was to analyze the mitigation of cytotoxic effects of endosulphan by α-tocopherol in kidneys of Cyprinus carpio in vitro. Cyprinus carpio kidney was cut into smaller pieces (1mm3) and divided into two experimental groups. One experimental group was exposed to endosulphan (100 nmolml-1) and second with endosulphan supplemented with -tocopherol (100 μmol L-1). After exposure of endosulphan, enlarged haemorrhage in the renal tubules, narrowing of tubular lumen, and pycnosis in nuclei were observed. Supplementation of á-tocopherol along with endosulphan exposure, no significant change in histoarchitecture of kidney was noticed after 1h. After 8 hours vacuoles in cytoplasm was reported in number of cells however these degenerative changes were not so prominent as observed in endosulphan exposed kidney tissue demonstrating that vitamin E supplementation provides mitigation in endosulphan induced renal toxicity.
- Subjects
PLANT protection research; WEED control research; HERBICIDE research; PESTICIDE research; CYPRINUS
- Publication
Advances in Pharmacology & Toxicology, 2015, Vol 16, Issue 1, p21
- ISSN
0973-2381
- Publication type
Article