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- Title
Virulence Factors and Carbapenem-Resistance Mechanisms in Hypervirulent Klebsiella Pneumoniae.
- Authors
Liao, Yiqun; Gong, Junjie; Yuan, Xiaoliang; Wang, Xiaoling; Huang, Yuanhong; Chen, Xiaohong
- Abstract
Hypervirulent Klebsiella pneumoniae (hvKP) has emerged as a novel variant of K. pneumoniae, exhibiting distinct phenotypic and genotypic characteristics that confer increased virulence and pathogenicity. It is not only responsible for nosocomial infections but also community-acquired infections, including liver abscesses, endophthalmitis, and meningitis, leading to significant morbidity and mortality. HvKP has been reported all over the world, but it is mainly prevalent in Asia Pacific, especially China. Moreover, hvKP can acquire carbapenemase genes resulting in the emergence of carbapenem-resistant hypervirulent K. pneumoniae (CR-hvKP), which possesses both high virulence and drug resistance capabilities. Consequently, CR-hvKP poses substantial challenges to infection control and presents serious threats to global public health. In this paper, we provide a comprehensive summary of the epidemiological characteristics, virulence factors, and mechanisms underlying carbapenem resistance in hvKP strains with the aim of offering valuable insights for practical prevention strategies as well as future research.
- Subjects
CHINA; PACIFIC Area; KLEBSIELLA pneumoniae; KLEBSIELLA infections; NOSOCOMIAL infections; LIVER abscesses; COMMUNITY-acquired infections; DRUG resistance; INFECTION control
- Publication
Infection & Drug Resistance, 2024, Vol 17, p1551
- ISSN
1178-6973
- Publication type
Article
- DOI
10.2147/IDR.S461903