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- Title
Selective contrast‐enhanced computed tomography is appropriate in diffuse large B‐cell lymphoma therapy response assessment.
- Authors
Kriegsmann, Katharina; Wack, Maurizio; Kriegsmann, Mark; Cremer, Martin; Bruckner, Thomas; Ho, Anthony D.; Wuchter, Patrick; Witzens‐Harig, Mathias
- Abstract
Objective: Although not the gold standard, contrast‐enhanced CT of neck, thorax, and abdomen/pelvis is routinely performed in diagnosis and response assessment of DLBCL. PD during first‐line treatment is a relatively rare event. The question arises if the imaging of initially involved regions only might be sufficient for response evaluation. Method: We retrospectively analyzed the data of 167 DLBCL patients who had an extensive contrast‐enhanced CT scan at first diagnosis. The majority of patients (n = 128, 77%) was treated with R‐CHOP. Therapy response was assessed as interim and end of treatment staging by contrast‐enhanced CT. Results: The overall response rate at the end of treatment was 94%. None of the patients showed involvement of new sites at interim staging. As a major finding, none of the patients showed an involvement of sites, which were not initially involved. Four patients developed PD during first‐line chemotherapy/after mid‐treatment staging and 31 relapsed. A conclusive comparison between initial and PD/relapse DLBCL involvement was possible in 27 patients: 8 patients did and 19 patients did not show additional/new sites of involvement compared to first diagnosis. Conclusion: Our retrospective analysis provides a rationale for selective imaging of initially involved DLBCL sites for therapy response assessment.
- Subjects
DIFFUSE large B-cell lymphomas; LYMPHOMAS; RESPONSE rates; COMPUTED tomography; TOMOGRAPHY
- Publication
European Journal of Haematology, 2018, Vol 101, Issue 5, p613
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.13150