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- Title
Pulmonary flow profile and distensibility following acute pulmonary embolism.
- Authors
Klok, Frederikus A.; Romeih, Soha; Westenberg, Jos J. M.; Kroft, Lucia J. M.; Huisman, Menno V.; de Roos, Albert
- Abstract
Objective: Proof of concept study evaluating CMR as screening tool for chronic thromboembolic pulmonary hypertension (CTEPH) in patients treated for acute pulmonary embolism (PE). Materials and methods: Right and left ventricular function of 15 consecutive patients treated for PE and 10 consecutive patients in whom PE was excluded was estimated at baseline by cardiac CT and at 6 months follow-up by CMR. Additionally, during the follow-up visit, pulmonary artery (PA) hemodynamics were studied by CMR and the presence of pulmonary hypertension by echocardiography. Results: CT measured right ventricular ejection fraction (RVEF) was lower in patients with PE compared to patients without PE at time of diagnosis (median 47%, interquartile range 39-53 vs. 55%, 52-58; p = 0.014). After 6 months follow up, the RVEF between patients treated for PE and patients without PE were not statistically significant different (55%, 52-60 versus 54%, 51-57; p = 0.57), as were distensibility index (0.18 ± 0.18 versus 0.25 ± 0.18, p = 0.20), mean velocity (14.1 ± 3.9 cm/s versus 14.0 ± 2.5 cm/s, p = 0.81), peak velocity (86.5 ± 22 cm/s versus 89.6 ± 13 cm/s, p = 0.43) and time to peak PA blood flow velocity (142 ± 49 ms versus 161 ± 29 ms, p = 0.14). One patient was diagnosed with CTEPH and CMR revealed poor right systolic function, decreased PA distensibility and flow velocity, and a systolic notch in the PA flow profile consistent with persistent PA obstruction. Conclusion: In this small series, right ventricular performance and PA flow profiles of patients treated for 6 months after PE are equivalent to those parameters in normal patients.
- Subjects
PULMONARY hypertension; PULMONARY embolism; CARDIAC imaging; DIAGNOSTIC ultrasonic imaging; ECHOCARDIOGRAPHY
- Publication
Journal of Cardiovascular Magnetic Resonance (BioMed Central), 2011, Vol 13, Issue 1, p14
- ISSN
1532-429X
- Publication type
Article
- DOI
10.1186/1532-429X-13-14