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- Title
Emerging insights into the relationship between pre-microRNA146a rs2910164 gene polymorphism and TNF-α in ischemic stroke.
- Authors
Elasmer, Shimaa Mohammed; Zaki, Osman; Elgendy, Hanan; Kamal, Manal; M. Abdel Halim, Radwa
- Abstract
This study investigated the association between the pre-miRNA146a C>G rs2910164 polymorphism and serum TNF-α in Egyptian patients with IS. A case-control study was conducted on 75 Egyptian cases with IS and 75 sex-matched control subjects aged 57–65 years. Genomic DNA analysis of pre-miRNA146a and TNF-α measurement was performed with real-time PCR and ELISA, respectively. There was a statistically significant difference between cases of ischemic stroke (IS) and control subjects in pre-miRNA146a rs2910164 GG genotype (p=0.017) and G allele (p=0.005). The pre-miRNA146a rs2910164 is significantly associated with large artery atherosclerosis [LAA] in GG genotypes (p=0.019) and G alleles (p=0.004) compared to control subjects. There was a highly statistically significant increase in TNF-α levels (p<0.001) in IS compared to the control group. There was also a statistically significant increase in TNF-α levels (p=0.001) in GG genotypes in IS. Our results showed that there was a statistically significant association between pre-miRNA146a rs2910164 GG genotype and susceptibility to IS and LAA. In addition, there was a statistically significant association between pre-miRNA146a rs2910164 GG genotype and TNF-α in IS subjects.
- Subjects
ISCHEMIC stroke; GENETIC polymorphisms; TUMOR necrosis factors; DNA analysis; GENOMICS; EGYPTIANS; SINGLE nucleotide polymorphisms
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2022, Vol 47, Issue 4, p523
- ISSN
0250-4685
- Publication type
Article
- DOI
10.1515/tjb-2021-0221