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Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.
Published in:
EMBO Journal, 2002, v. 21, n. 14, p. 3782, doi. 10.1093/emboj/cdf361
By:
- Ouwens, D. Margriet;
- de Ruiter, Nancy D.;
- van Der Zon, Gerard C. M.;
- Carter, Andrew P.;
- Schouten, Jan;
- van Der Burgt, Corina;
- Kooistra, Klaas;
- Bos, Johannes L.;
- Maassen, J. Antonie;
- van Dam, Hans
Publication type:
Article
Crosstalk of Diabetic Conditions with Static Versus Dynamic Flow Environment—Impact on Aortic Valve Remodeling.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 13, p. 6976, doi. 10.3390/ijms22136976
By:
- Selig, Jessica I.;
- Boulgaropoulos, Joana;
- Niazy, Naima;
- Ouwens, D. Margriet;
- Preuß, Karlheinz;
- Horn, Patrick;
- Westenfeld, Ralf;
- Lichtenberg, Artur;
- Akhyari, Payam;
- Barth, Mareike
Publication type:
Article
Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 11, p. 4144, doi. 10.3390/ijms21114144
By:
- Fahlbusch, Pia;
- Knebel, Birgit;
- Hörbelt, Tina;
- Barbosa, David Monteiro;
- Nikolic, Aleksandra;
- Jacob, Sylvia;
- Al-Hasani, Hadi;
- Van de Velde, Frederique;
- Van Nieuwenhove, Yves;
- Müller-Wieland, Dirk;
- Lapauw, Bruno;
- Ouwens, D. Margriet;
- Kotzka, Jorg
Publication type:
Article
CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes.
Published in:
Biochemical Journal, 2012, v. 448, n. 1, p. 43, doi. 10.1042/BJ20120060
By:
- ANGIN, Yeliz;
- STEINBUSCH, Laura K. M.;
- SIMONS, Peter J.;
- GREULICH, Sabrina;
- HOEBERS, Nicole T. H.;
- DOUMA, Kim;
- VAN ZANDVOORT, Marc A. M. J.;
- COUMANS, Will A.;
- WIJNEN, Wino;
- DIAMANT, Michaela;
- OUWENS, D. Margriet;
- GLATZ, Jan F. C.;
- LUIKEN, Joost J. F. P.
Publication type:
Article
One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension.
Published in:
Diabetologia, 2020, v. 63, n. 6, p. 1211, doi. 10.1007/s00125-020-05128-1
By:
- Bilet, Lena;
- Phielix, Esther;
- van de Weijer, Tineke;
- Gemmink, Anne;
- Bosma, Madeleen;
- Moonen-Kornips, Esther;
- Jorgensen, Johanna A.;
- Schaart, Gert;
- Zhang, Dongyan;
- Meijer, Kenneth;
- Hopman, Maria;
- Hesselink, Matthijs K. C.;
- Ouwens, D. Margriet;
- Shulman, Gerald I.;
- Schrauwen-Hinderling, Vera B.;
- Schrauwen, Patrick
Publication type:
Article
Postprandial renal haemodynamic effects of the dipeptidyl peptidase‐4 inhibitor linagliptin versus the sulphonylurea glimepiride in adults with type 2 diabetes (RENALIS): A predefined substudy of a randomized, double‐blind trial.
Published in:
Diabetes, Obesity & Metabolism, 2022, v. 24, n. 1, p. 115, doi. 10.1111/dom.14557
By:
- Muskiet, Marcel H. A.;
- Tonneijck, Lennart;
- Smits, Mark M.;
- Kramer, Mark H. H.;
- Ouwens, D. Margriet;
- Hartmann, Bolette;
- Holst, Jens J.;
- Danser, A. H. Jan;
- Joles, Jaap A.;
- van Raalte, Daniël H.
Publication type:
Article
Effects of dipeptidyl peptidase‐4 inhibitor linagliptin versus sulphonylurea glimepiride on systemic haemodynamics in overweight patients with type 2 diabetes: A secondary analysis of an 8‐week, randomized, controlled, double‐blind trial
Published in:
Diabetes, Obesity & Metabolism, 2020, v. 22, n. 10, p. 1847, doi. 10.1111/dom.14107
By:
- Kraaijenhof, Jordan;
- Muskiet, Marcel H. A.;
- Tonneijck, Lennart;
- Ouwens, D. Margriet;
- Kramer, Mark H. H.;
- Raalte, Daniël H.;
- Smits, Mark M.
Publication type:
Article
Combined Gene and Protein Expression of Hormone-Sensitive Lipase and Adipose Triglyceride Lipase, Mitochondrial Content, and Adipocyte Size in Subcutaneous and Visceral Adipose Tissue of Morbidly Obese Men.
Published in:
Obesity Facts: The European Journal of Obesity, 2011, v. 4, n. 5, p. 407, doi. 10.1159/000333445
By:
- De Naeyer, Hélène;
- Ouwens, D. Margriet;
- Van Nieuwenhove, Yves;
- Pattyn, Piet;
- 't Hart, Leen M.;
- Kaufman, Jean-Marc;
- Sell, Henrike;
- Eckel, Juergen;
- Cuvelier, Claude;
- Taes, Youri E.;
- Ruige, Johannes B.
Publication type:
Article
Effect of Sfrp5 on Cytokine Release and Insulin Action in Primary Human Adipocytes and Skeletal Muscle Cells.
Published in:
PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0085906
By:
- Carstensen, Maren;
- Wiza, Claudia;
- Röhrig, Karin;
- Fahlbusch, Pia;
- Roden, Michael;
- Herder, Christian;
- Ouwens, D. Margriet
Publication type:
Article
Cardioprotective Properties of Omentin-1 in Type 2 Diabetes: Evidence from Clinical and <i>In Vitro</i> Studies.
Published in:
PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0059697
By:
- Greulich, Sabrina;
- Chen, Weena J. Y.;
- Maxhera, Bujar;
- Rijzewijk, Luuk J.;
- van der Meer, Rutger W.;
- Jonker, Jacqueline T.;
- Mueller, Heidi;
- de Wiza, Daniella Herzfeld;
- Floerke, Ralf-Ruediger;
- Smiris, Konstantinos;
- Lamb, Hildo J.;
- de Roos, Albert;
- Bax, Jeroen J.;
- Romijn, Johannes A.;
- Smit, Jan W. A.;
- Akhyari, Payam;
- Lichtenberg, Artur;
- Eckel, Juergen;
- Diamant, Michaela;
- Ouwens, D. Margriet
Publication type:
Article
Glucose Intolerance and the Amount of Visceral Adipose Tissue Contribute to an Increase in Circulating Triglyceride Concentrations in Caucasian Obese Females.
Published in:
PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0045145
By:
- Berings, Margot;
- Wehlou, Charline;
- Verrijken, An;
- Deschepper, Ellen;
- Mertens, Ilse;
- Kaufman, Jean-Marc;
- Van Gaal, Luc F.;
- Ouwens, D. Margriet;
- Ruige, Johannes B.;
- Atkin, Stephen L.
Publication type:
Article
Activin A impairs insulin action in cardiomyocytes via up-regulation of miR-143.
Published in:
Cardiovascular Research, 2013, v. 100, n. 2, p. 201, doi. 10.1093/cvr/cvt173
By:
- Blumensatt, Marcel;
- Greulich, Sabrina;
- Herzfeld de Wiza, Daniella;
- Mueller, Heidi;
- Maxhera, Bujar;
- Rabelink, Martijn J.;
- Hoeben, Rob C.;
- Akhyari, Payam;
- Al-Hasani, Hadi;
- Ruige, Johannes B.;
- Ouwens, D. Margriet
Publication type:
Article
Adiponectin may mediate the association between omentin, circulating lipids and insulin sensitivity: results from the KORA F4 study.
Published in:
European Journal of Endocrinology, 2015, v. 172, n. 4, p. 423, doi. 10.1530/EJE-14-0879
By:
- Herder, Christian;
- Ouwens, D. Margriet;
- Carstensen, Maren;
- Kowall, Bernd;
- Huth, Cornelia;
- Meisinger, Christa;
- Rathmann, Wolfgang;
- Roden, Michael;
- Thorand, Barbara
Publication type:
Article
Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial.
Published in:
European Journal of Endocrinology, 2014, v. 170, n. 3, p. 429, doi. 10.1530/EJE-13-0610
By:
- van Genugten, Renate E.;
- van Raalte, Daniël H.;
- Muskiet, Marcel H.;
- Heymans, Martijn W.;
- Pouwels, Petra J. W.;
- Ouwens, D. Margriet;
- Mari, Andrea;
- Diamant, Michaela
Publication type:
Article
Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function.
Published in:
Cardiovascular Diabetology, 2016, v. 15, p. 1, doi. 10.1186/s12933-016-0410-9
By:
- Hartmann, Thorsten;
- Overhagen, Sabrina;
- Ouwens, D. Margriet;
- Raschke, Silja;
- Wohlfart, Paulus;
- Tennagels, Norbert;
- Wronkowitz, Nina;
- Eckel, Jürgen
Publication type:
Article
Activin a is associated with impaired myocardial glucose metabolism and left ventricular remodeling in patients with uncomplicated type 2 diabetes.
Published in:
Cardiovascular Diabetology, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1475-2840-12-150
By:
- Chen, Weena J. Y.;
- Greulich, Sabrina;
- van der Meer, Rutger W.;
- Rijzewijk, Luuk J.;
- Lamb, Hildo J.;
- de Roos, Albert;
- Smit, Johannes W. A.;
- Romijn, Johannes A.;
- Ruige, Johannes B.;
- Lammertsma, Adriaan A.;
- Lubberink, Mark;
- Diamant, Michaela;
- Ouwens, D. Margriet
Publication type:
Article
Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle.
Published in:
Cardiovascular Diabetology, 2010, v. 9, p. 25, doi. 10.1186/1475-2840-9-25
By:
- van den Brom, Charissa E.;
- Bosmans, Joanna W. A. M.;
- Vlasblom, Ronald;
- Handoko, Louis M.;
- Huisman, Marc C.;
- Lubberink, Mark;
- Molthoff, Carla F. M.;
- Lammertsma, Adriaan A.;
- Ouwens, Margriet D.;
- Diamant, Michaela;
- Boer, Christa
Publication type:
Article
Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-61886-3
By:
- Barbosa, David Monteiro;
- Fahlbusch, Pia;
- Herzfeld de Wiza, Daniella;
- Jacob, Sylvia;
- Kettel, Ulrike;
- Al-Hasani, Hadi;
- Krüger, Martina;
- Ouwens, D. Margriet;
- Hartwig, Sonja;
- Lehr, Stefan;
- Kotzka, Jorg;
- Knebel, Birgit
Publication type:
Article
Secretory products of guinea pig epicardial fat induce insulin resistance and impair primary adult rat cardiomyocyte function.
Published in:
Journal of Cellular & Molecular Medicine, 2011, v. 15, n. 11, p. 2399, doi. 10.1111/j.1582-4934.2010.01232.x
By:
- Greulich, Sabrina;
- de Wiza, Daniella Herzfeld;
- Preilowski, Sebastian;
- Ding, Zhaoping;
- Mueller, Heidi;
- Langin, Dominique;
- Jaquet, Kornelia;
- Ouwens, D. Margriet;
- Eckel, Juergen
Publication type:
Article
The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease.
Published in:
Journal of Cellular & Molecular Medicine, 2010, v. 14, n. 9, p. 2223, doi. 10.1111/j.1582-4934.2010.01141.x
By:
- Ouwens, D. Margriet;
- Sell, Henrike;
- Greulich, Sabrina;
- Eckel, Juergen
Publication type:
Article
THE SMALL CHAIN FATTY ACID BUTYRATE ANTAGONIZES THE TCR-STIMULATION-INDUCED METABOLIC SHIFT IN MURINE EPIDERMAL γδ T CELLS.
Published in:
EXCLI Journal, 2020, v. 19, p. 334, doi. 10.17179/excli2020-1123
By:
- Häselbarth, Lukas;
- Ouwens, D. Margriet;
- Teichweyde, Nadine;
- Hochrath, Katrin;
- Merches, Katja;
- Esser, Charlotte
Publication type:
Article
VEGF in the Crosstalk between Human Adipocytes and Smooth Muscle Cells: Depot-Specific Release from Visceral and Perivascular Adipose Tissue.
Published in:
Mediators of Inflammation, 2013, v. 2013, p. 1, doi. 10.1155/2013/982458
By:
- Schlich, Raphaela;
- Willems, Miriam;
- Greulich, Sabrina;
- Ruppe, Florian;
- Trudo Knoefel, Wolfram;
- Ouwens, D. Margriet;
- Maxhera, Bujar;
- Lichtenberg, Artur;
- Eckel, Jürgen;
- Sell, Henrike
Publication type:
Article
Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation.
Published in:
2008
By:
- van den Hoek AM;
- van Heijningen C;
- Schröder-van der Elst JP;
- Ouwens DM;
- Havekes LM;
- Romijn JA;
- Kalsbeek A;
- Pijl H;
- van den Hoek, Anita M;
- van Heijningen, Caroline;
- Schröder-van der Elst, Janny P;
- Ouwens, D Margriet;
- Havekes, Louis M;
- Romijn, Johannes A;
- Kalsbeek, Andries;
- Pijl, Hanno
Publication type:
journal article
Intracerebroventricular Administration of Neuropeptide Y Induces Hepatic Insulin Resistance via Sympathetic Innervation.
Published in:
Diabetes, 2008, v. 57, n. 9, p. 2304, doi. 10.2337/db07-1658
By:
- van den Hoek, Anita M.;
- van Heijningen, Caroline;
- Schröder-van der Elst, Janny P.;
- Ouwens, D. Margriet;
- Havekes, Louis M.;
- Romijn, Johannes A.;
- Kalsbeek, Andries;
- Pijl, Hanno
Publication type:
Article
Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet-Fed Rats.
Published in:
Diabetes, 2006, v. 55, n. 12, p. 3221, doi. 10.2337/db05-1390
By:
- Nascimento, Emmani B. M.;
- Fodor, Mariann;
- van der Zon, Gerard C. M.;
- Jazet, Ingrid M.;
- Meinders, A. Edo;
- Voshol, Peter J.;
- Vlasblom, Ronald;
- Baan, Bart;
- Eckel, Jürgen;
- Maassen, J. Antonie;
- Diamant, Michaela;
- Ouwens, D. Margriet
Publication type:
Article
Hepatic Wnt1 Inducible Signaling Pathway Protein 1 (WISP-1/CCN4) Associates with Markers of Liver Fibrosis in Severe Obesity.
Published in:
Cells (2073-4409), 2021, v. 10, n. 5, p. 1048, doi. 10.3390/cells10051048
By:
- Pivovarova-Ramich, Olga;
- Loske, Jennifer;
- Hornemann, Silke;
- Markova, Mariya;
- Seebeck, Nicole;
- Rosenthal, Anke;
- Klauschen, Frederick;
- Castro, José Pedro;
- Buschow, René;
- Grune, Tilman;
- Lange, Volker;
- Rudovich, Natalia;
- Ouwens, D. Margriet;
- Nilsson, Tommy;
- Metrakos, Peter;
- Lazaris, Anthoula
Publication type:
Article
Increased Glycolysis and Higher Lactate Production in Hyperglycemic Myotubes.
Published in:
Cells (2073-4409), 2019, v. 8, n. 9, p. 1101, doi. 10.3390/cells8091101
By:
- Lund, Jenny;
- Ouwens, D. Margriet;
- Wettergreen, Marianne;
- Bakke, Siril S.;
- Thoresen, G. Hege;
- Aas, Vigdis
Publication type:
Article
Sfrp5 increases glucose-stimulated insulin secretion in the rat pancreatic beta cell line INS-1E.
Published in:
PLoS ONE, 2019, v. 14, n. 3, p. 1, doi. 10.1371/journal.pone.0213650
By:
- Carstensen-Kirberg, Maren;
- Röhrig, Karin;
- Niersmann, Corinna;
- Ouwens, D. Margriet;
- Belgardt, Bengt F.;
- Roden, Michael;
- Herder, Christian
Publication type:
Article
Increased triacylglycerol - Fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid.
Published in:
PLoS ONE, 2018, v. 13, n. 11, p. 1, doi. 10.1371/journal.pone.0208048
By:
- Løvsletten, Nils G.;
- Bakke, Siril S.;
- Kase, Eili T.;
- Ouwens, D. Margriet;
- Thoresen, G. Hege;
- Rustan, Arild C.
Publication type:
Article
Effects of DPP-4 Inhibitor Linagliptin Versus Sulfonylurea Glimepiride as Add-on to Metformin on Renal Physiology in Overweight Patients With Type 2 Diabetes (RENALIS): A Randomized, Double-Blind Trial.
Published in:
2020
By:
- Muskiet, Marcel H.A.;
- Tonneijck, Lennart;
- Smits, Mark M.;
- Kramer, Mark H.H.;
- Ouwens, D. Margriet;
- Hartmann, Bolette;
- Holst, Jens J.;
- Touw, Daan J.;
- Danser, A.H. Jan;
- Joles, Jaap A.;
- van Raalte, Daniël H.
Publication type:
journal article
Glucagon-like peptide-1 receptor agonist treatment prevents glucocorticoid-induced glucose intolerance and islet-cell dysfunction in humans.
Published in:
2011
By:
- van Raalte DH;
- van Genugten RE;
- Linssen MM;
- Ouwens DM;
- Diamant M;
- van Raalte, Daniël H;
- van Genugten, Renate E;
- Linssen, Margot M L;
- Ouwens, D Margriet;
- Diamant, Michaela
Publication type:
journal article
Glucagon-Like Peptide. 1 Receptor Agonist Treatment Prevents Glucocorticoid-Induced Glucose Intolerance and Islet-Cell Dysfunction in Humans.
Published in:
Diabetes Care, 2011, v. 34, n. 2, p. 412, doi. 10.2337/dc10-1677
By:
- VAN RAALTE, DANIËL H.;
- VAN GENUGTEN, RENATE E.;
- LINSSEN, MARGOT M. L.;
- OUWENS, D. MARGRIET;
- DIAMANT, MICHAELA
Publication type:
Article
Secretory products from epicardial adipose tissue from patients with type 2 diabetes impair mitochondrial β-oxidation in cardiomyocytes via activation of the cardiac renin–angiotensin system and induction of miR-208a.
Published in:
Basic Research in Cardiology, 2017, v. 112, n. 1, p. 1, doi. 10.1007/s00395-016-0591-0
By:
- Blumensatt, Marcel;
- Fahlbusch, Pia;
- Hilgers, Rebecca;
- Bekaert, Marlies;
- Herzfeld de Wiza, Daniella;
- Akhyari, Payam;
- Ruige, Johannes B.;
- Ouwens, D. Margriet
Publication type:
Article
Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in patients with obesity.
Published in:
2016
By:
- Bekaert, Marlies;
- Ouwens, D. Margriet;
- Hörbelt, Tina;
- Van de Velde, Frederique;
- Fahlbusch, Pia;
- Herzfeld de Wiza, Daniella;
- Van Nieuwenhove, Yves;
- Calders, Patrick;
- Praet, Marleen;
- Hoorens, Anne;
- Geerts, Anja;
- Verhelst, Xavier;
- Kaufman, Jean‐Marc;
- Lapauw, Bruno;
- Hörbelt, Tina;
- Kaufman, Jean-Marc
Publication type:
journal article
Tissue-Specific Differences in the Development of Insulin Resistance in a Mouse Model for Type 1 Diabetes.
Published in:
Diabetes, 2014, v. 63, n. 11, p. 3856, doi. 10.2337/db13-1794
By:
- Jelenik, Tomas;
- Séquaris, Gilles;
- Kaul, Kirti;
- Ouwens, D. Margriet;
- Phielix, Esther;
- Kotzka, Jörg;
- Knebel, Birgit;
- Weiß, Jürgen;
- Reinbeck, Anna Lena;
- Janke, Linda;
- Nowotny, Peter;
- Partke, Hans-Joachim;
- Dongyan Zhang;
- Shulman, Gerald I.;
- Szendroedi, Julia;
- Roden, Michael
Publication type:
Article
High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance.
Published in:
2012
By:
- Phielix E;
- Meex R;
- Ouwens DM;
- Sparks L;
- Hoeks J;
- Schaart G;
- Moonen-Kornips E;
- Hesselink MK;
- Schrauwen P;
- Phielix, Esther;
- Meex, Ruth;
- Ouwens, D Margriet;
- Sparks, Lauren;
- Hoeks, Joris;
- Schaart, Gert;
- Moonen-Kornips, Esther;
- Hesselink, Matthijs K C;
- Schrauwen, Patrick
Publication type:
journal article
High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance.
Published in:
Diabetes, 2012, v. 61, n. 10, p. 2472, doi. 10.2337/db11-1832
By:
- Phielix, Esther;
- Meex, Ruth;
- Ouwens, D. Margriet;
- Sparks, Lauren;
- Hoeks, Joris;
- Schaart, Gert;
- Moonen-Kornips, Esther;
- Hesselink, Matthijs K. C.;
- Schrauwen, Patrick
Publication type:
Article
Heat Shock Protein 60 as a Mediator of Adipose Tissue Inflammation and Insulin Resistance.
Published in:
Diabetes, 2012, v. 61, n. 3, p. 615, doi. 10.2337/db10-1574
By:
- Mäirker, Tina;
- Sell, Henrike;
- Zillesen, Pia;
- Glöde, Anja;
- Kriebel, Jennifer;
- Ouwens, D. Margriet;
- Pattyn, Piet;
- Ruige, Johannes;
- Famulla, Susanne;
- Roden, Michael;
- Eckel, Jürgen;
- Habich, Christiane
Publication type:
Article
Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome.
Published in:
Diabetes, 2011, v. 60, n. 7, p. 1917, doi. 10.2337/db10-1707
By:
- Lamers, Daniela;
- Famulla, Susanne;
- Wronkowitz, Nina;
- Hartwig, Sonja;
- Lehr, Stefan;
- Margriet-Ouwens, D.;
- Eckardt, Kristin;
- Kaufman, Jean M.;
- Ryden, Mikael;
- Müller, Stefan;
- Hanisch, Franz-Georg;
- Ruige, Johannes;
- Arner, Peter;
- Sell, Henrike;
- Eckel, Juergen
Publication type:
Article

Found: 39