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- Title
Host genetic factors in susceptibility to mycobacterial disease.
- Authors
Duncan, Christopher JA; Hambleton, Sophie
- Abstract
Primary immunodeficiencies (PID) are a group of rare inherited disorders that manifest as heightened susceptibility to infection, autoimmunity and/or malignancy. By exploring their genetic and cellular aetiology, we can learn much about the basis of pathogen-specific immunity in humans. This is exemplified by mycobacterial susceptibility, which occurs across several types of PID, either as an isolated problem or as part of a broader pattern of susceptibility to infection. These experiments of nature have contributed to our understanding of the central role of T cells in activating infected macrophages to eliminate phagosomal mycobacteria through mutually activating, cytokine-dependent interactions. In recent years, the discovery of novel forms of PID has emphasised the important role of dendritic cells and monocytes in mycobacterial defence in humans. Here, we provide a brief overview of these new disorders alongside other genetic causes of susceptibility to mycobacterial disease.
- Subjects
GENETICS of disease susceptibility; DENDRITIC cells; GENETIC mutation; GENETICS; MYCOBACTERIAL diseases; DISEASE risk factors
- Publication
Clinical Medicine, 2014, Vol 14, ps17
- ISSN
1470-2118
- Publication type
Article
- DOI
10.7861/clinmedicine.14-6-s17