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- Title
Critical illness-associated diaphragm weakness.
- Authors
Dres, Martin; Goligher, Ewan; Heunks, Leo; Brochard, Laurent; Goligher, Ewan C; Heunks, Leo M A; Brochard, Laurent J
- Abstract
Diaphragm weakness is highly prevalent in critically ill patients. It may exist prior to ICU admission and may precipitate the need for mechanical ventilation but it also frequently develops during the ICU stay. Several risk factors for diaphragm weakness have been identified; among them sepsis and mechanical ventilation play central roles. We employ the term critical illness-associated diaphragm weakness to refer to the collective effects of all mechanisms of diaphragm injury and weakness occurring in critically ill patients. Critical illness-associated diaphragm weakness is consistently associated with poor outcomes including increased ICU mortality, difficult weaning, and prolonged duration of mechanical ventilation. Bedside techniques for assessing the respiratory muscles promise to improve detection of diaphragm weakness and enable preventive or curative strategies. Inspiratory muscle training and pharmacological interventions may improve respiratory muscle function but data on clinical outcomes remain limited.
- Subjects
DIAPHRAGM diseases; CRITICALLY ill; ARTIFICIAL respiration; CRITICAL care medicine; RESPIRATORY muscles; DIAPHRAGM injuries; AIRWAY (Anatomy); CATASTROPHIC illness; DIAPHRAGM (Anatomy); ELECTROMYOGRAPHY; INTENSIVE care units; ADULT respiratory distress syndrome; MUSCULAR atrophy; SEPSIS; ULTRASONIC imaging; DISEASE complications; MUSCLE weakness; PREVENTION
- Publication
Intensive Care Medicine, 2017, Vol 43, Issue 10, p1441
- ISSN
0342-4642
- Publication type
journal article
- DOI
10.1007/s00134-017-4928-4