We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of brain arterial diameters with demographic and anatomical factors in a multi-national pooled analysis of cohort studies.
- Authors
Del Brutto, Victor J; Khasiyev, Farid; Liu, Minghua; Spagnolo-Allende, Antonio; Qiao, Ye; Melgarejo Arias, Jesus D; Guzman, Vanessa A; Igwe, Kay C; Sanchez, Danurys L; Andrews, Howard; Morales, Clarissa D; Farrell, Meagan T; Bassil, Darina T; Seshadri, Sudha; Wagner, Ryan G; Mngomezulu, Victor; Manly, Jennifer; Elkind, Mitchell SV; Berkman, Lisa; Romero, Jose R
- Abstract
Background and Purpose: Brain arterial diameters are markers of cerebrovascular disease. Demographic and anatomical factors may influence arterial diameters. We hypothesize that age, sex, height, total cranial volume (TCV), and persistent fetal posterior cerebral artery (fPCA) correlate with brain arterial diameters across populations. Methods: Participants had a time-of-flight MRA from nine international cohorts. Arterial diameters of the cavernous internal carotid arteries (ICA), middle cerebral arteries (MCA), and basilar artery (BA) were measured using LAVA software. Regression models assessed the association between exposures and brain arterial diameters. Results: We included 6,518 participants (mean age: 70 ± 9 years; 41% men). Unilateral fPCA was present in 13.2% and bilateral in 3.2%. Larger ICA, MCA, and BA diameters correlated with older age (Weighted average [WA] per 10 years: 0.18 mm, 0.11 mm, and 0.12 mm), male sex (WA: 0.24 mm, 0.13 mm, and 0.21 mm), and TCV (WA: for one TCV standard deviation: 0.24 mm, 0.29 mm, and 0.18 mm). Unilateral and bilateral fPCAs showed a positive correlation with ICA diameters (WA: 0.39 mm and 0.73 mm) and negative correlation with BA diameters (WA: −0.88 mm and −1.73 mm). Regression models including age, sex, TCV, and fPCA explained on average 15%, 13%, and 25% of the ICA, MCA, and BA diameter interindividual variation, respectively. Using height instead of TCV as a surrogate of head size decreased the R-squared by 3% on average. Conclusion: Brain arterial diameters correlated with age, sex, TCV, and fPCA. These factors should be considered when defining abnormal diameter cutoffs across populations.
- Subjects
CEREBROVASCULAR disease risk factors; STATISTICAL correlation; CAROTID artery; RESEARCH funding; BASILAR artery; SEX distribution; AGE distribution; DESCRIPTIVE statistics; HEAD; CEREBRAL arteries; STATURE; LONGITUDINAL method; POSTERIOR cerebral artery; RESEARCH; MAGNETIC resonance angiography; DATA analysis software; REGRESSION analysis; BIOMARKERS
- Publication
Neuroradiology Journal, 2024, Vol 37, Issue 3, p304
- ISSN
1971-4009
- Publication type
Article
- DOI
10.1177/19714009231224429