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- Title
Can Upregulation of CXCR3 By Phototherapy Improve Vitiligo? It's Role in Chronicity.
- Authors
Al-Zahraa, Fatma; Hay, Nesma Hussein Abdel; Adel, Seham; Diab, Heba Mahmoud; Mansour, Amal
- Abstract
Background: Vitiligo is melanocyte death that is affected by oxidative stress which elevated levels of reactive oxygen species can elicit an immune response, and ultimately cause melanocytic death. Objective: The current study aimed to investigate the impact of Narrowband Ultraviolet B (NBUVB) and excimer laser phototherapy on C-X-C motif chemokine receptor 3B expression in vitiligo patients and its impact on vitiligo improvement. Patients and methods: CXCR3B mRNA expression was measured in skin of 25 patients suffering from non-segmental vitiligo before and after generalized 'NBUVB' and targeted phototherapy 'Excimer laser'. All biopsies were kept in - 80C till RNA extraction that was performed utilizing QIAGEN RNeasy Little Pack, QuantiTect Switch Record Unit and QuantiNova SYBR Green PCR Unit. Results: After phototherapy patients with vitiligo had higher CXCR3B mRNA levels, in addition, this was higher in excimer bunch treatment than NBUVB. Conclusion: Such findings draw attention to CXCR3B as an inherited abnormality in vitiligo patients' skin and raise concerns about its potential contributions in maintaining vitiligo or triggering relapses & chronicity.
- Subjects
VITILIGO; CHEMOKINE receptors; PHOTOTHERAPY; EXCIMER lasers; REACTIVE oxygen species
- Publication
Egyptian Journal of Hospital Medicine, 2023, Vol 92, Issue 1, p5595
- ISSN
1687-2002
- Publication type
Article
- DOI
10.21608/ejhm.2023.306171