Reports that the crystal structure of human matrix metalloproteinase type two (MMP-2), a key target for several anticancer therapies, has now been solved to a 2.8Å resolution. Reference to 1999 issue of the journal 'Science,' vol. 284, 1667-1670; Secretion of MMP-2 in the form of proenzyme that becomes partially activated upon proteolysis; Use of a combination of x-ray crystallogrphy and molecular replacement modelling.