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- Title
Utility of first positron emission tomography‐computed tomography scan as a prognostic tool following treatment of sinonasal and skull base malignancies.
- Authors
Abu‐Ghanem, Sara; Yafit, Daniel; Ghanayem, Mohamad; Abergel, Avraham; Yehuda, Moshe; Fliss, Dan M.
- Abstract
Background: The prognostic value of the first posttreatment whole body integrated positron emission tomography‐computed tomography (PET/CT) scanning in patients with sinonasal/skull base malignancies is undetermined. Methods: We retrospectively reviewed the data of all patients that underwent surgery for sinonasal/skull base malignancies in 2000‐2015. The results of the pretreatment and posttreatment PET/CT findings and the clinical course were retrieved. Results: Thirty‐eight patients (average age 60.6 years, 20 males) were included. Sensitivity and specificity, positive predictive value, and negative predictive value of the first PET/CT scan for predicting persistent/recurrent disease were 85.7%, 87.5%, 80%, and 91.3%, respectively. Overall 5‐year survival was significantly lower in the first posttreatment PET/CT‐positive group (35%) compared to the PET/CT‐negative group (93%) (P = .0008). Conclusion: Posttreatment PET/CT findings are highly prognostic in patients with sinonasal/skull base malignancies. Negative findings on the first posttreatment PET/CT scan predict a significantly better overall survival.
- Subjects
SKULL surgery; SKULL base; POSITRON emission tomography
- Publication
Head & Neck, 2019, Vol 41, Issue 3, p701
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.25416