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- Title
Differential chemotactic potential of mouse platelet basic protein for thymocyte subsets.
- Authors
W. X. Fu; S. Y. Gong; X. P. Qian; Y. Li; M. L. Zhu; X. Y. Dong; W. F. Chen
- Abstract
Mouse platelet basic protein (CXCL7/mPBP) was cloned from thymic stromal cells and further identification indicated that it was expressed in thymic monocytes/macrophages (Mo/Mfs). Recombinant mPBP was chemoattractive for target cells of polymorphonuclear leucocytes, peritoneal Mo/Mfs and splenic lymphocytes with distinct potencies. CXCR2 was identified to be a cognate receptor for mPBP. Mouse thymocyte subsets of CD4 -CD8 - double-negative (DN), CD4 +CD8 + double-positive (DP), CD4 +CD8 - single-positive (CD4SP) and CD4 -CD8 + single-positive (CD8SP) expressed cell surface CXCR2 with different positive percentages and expression levels. mPBP was chemoattractive for thymocyte subsets with the potency order DN>DP> CD8SP>CD4SP, consistent with the levels of CXCR2 expressed on the respective cells. Thus, mPBP in thymus is functionally redundant with chemokine CXCL12/ SDF-1. Moreover, our finding that thymic Mo/Mfs can produce mPBP implies that they may have other functions apart from acting as scavengers in thymus.
- Subjects
PROTEINS; CELLS; BIOMOLECULES; MACROPHAGES; LEUCOCYTES
- Publication
Cellular & Molecular Life Sciences, 2004, Vol 61, Issue 15, p1935
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-004-4137-5