We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Screening for Celiac Disease in Newly Diagnosed Children with Type I Diabetes.
- Authors
El Samahy, M. H.; Thabet, R. A.; Ragab, D. A.; Ibrahim, S. I.
- Abstract
Background: Type I diabetes (T1D) is an autoimmune disease caused by the immune-mediated destruction of insulin-producing pancreatic b cells.. Celiac disease is 5-7 percent more common in people with T1D than in the general population. Objectives: The aim of this study was to detect the incidence of coeliac disease among newly diagnosed T1D children by assessment of Anti-tissue Transglutaminase Antibody (anti-tTG), IgA. Methods: Fifty children with newly diagnosed T1D and another 15 age and sex –matched healthy individuals were subjected to screening for celiac disease by measuring total body IgA and antiTtg(IgA). Results: the incidence of positive anti tTG(IgA) Ab among our T1D patients was found to be 12%. Upon comparing children with positive anti tTG(IgA) Ab with those with negative anti tTG(IgA) Ab we found that children with þve anti tTG(IgA) Ab were significantly shorter than those with -ve anti tTG(IgA) Ab(p<0.05). Also HbA1c among our diabetic children with þve anti tTG(IgA) Ab was significantly higher than those with -ve anti tTG(IgA) (p<0.05). Gastrointestinal manifestations were significantly higher among T1D patients with anti tTG (IgA)þve than those with anti tTG(IgA)- ve.(p<0.001). Conclusion: Anti tTG(IgA) Ab levels are elevated in children and adolescents with type 1 diabetes compared with healthy controls with incidence rate of about 12%. Anti tTG(IgA) Ab test can be used as screening test for celiac disease among type1 DM.
- Subjects
CELIAC disease; TYPE 1 diabetes; PANCREATIC beta cells; IMMUNOGLOBULIN A; TEENAGERS; AUTOIMMUNE diseases
- Publication
QJM: An International Journal of Medicine, 2021, Vol 114, pi302
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcab113.058