We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Optogenetic Stimulation of MCH Neurons Increases Sleep.
- Authors
Konadhode, Roda Rani; Pelluru, Dheeraj; Bianco-Centurion, Carlos; Zayachkivsky, Andrew; Liu, Meng; Uhde, Thomas; Glen Jr, W. Bailey; van den Pol, Anthony N.; Mulholland, Patrick J.; Shiromani, Priyattam J.
- Abstract
Melanin concentrating hormone (MCH) is a cyclic neuropeptide present in the hypothalamus of all vertebrates. MCH is implicated in a number of behaviors but direct evidence is lacking. To selectively stimulate the MCH neurons the gene for the light-sensitive cation channel, channelrhodopsin-2, was inserted into the MCH neurons of wild-type mice. Three weeks later MCH neurons were stimulated for 1 min every 5 min for 24 h. A 10 Hz stimulation at the start of the night hastened sleep onset, reduced length of wake bouts by 50%, increased total time in non-REM and REM sleep at night, and increased sleep intensity during the day cycle. Sleep induction at a circadian time when all of the arousal neurons are active indicates that MCH stimulation can powerfully counteract the combined wake-promoting signal of the arousal neurons. This could be potentially useful in treatment of insomnia.
- Subjects
NEURAL stimulation; MELANIN-concentrating hormone; NEURONS; SOMNOLOGY; INSOMNIA treatment; RHODOPSIN
- Publication
Journal of Neuroscience, 2013, Vol 33, Issue 25, p10257
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.1225-13.2013