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- Title
Associations of the lactase persistence allele and lactose intake with body composition among multiethnic children.
- Authors
Malek, Adil; Klimentidis, Yann; Kell, Kenneth; Fernández, José
- Abstract
Childhood obesity is a worldwide health concern with a multifaceted and sometimes confounding etiology. Dairy products have been implicated as both pro- and anti-obesogenic, perhaps due to the confounding relationship between dairy, lactose consumption, and potential genetic predisposition. We aimed to understand how lactase persistence influenced obesity-related traits by observing the relationships among lactose consumption, a single nucleotide polymorphism (SNP) near the lactase ( LCT) gene and body composition parameters in a sample of multiethnic children ( n = 296, 7-12 years old). We hypothesized that individuals with the lactase persistence (LP) allele of the LCT SNP (rs4988235) would exhibit a greater degree of adiposity and that this relationship would be mediated by lactose consumption. Body composition variables were measured using dual X-ray absorptiometry and a registered dietitian assessed dietary intake of lactose. Statistical models were adjusted for sex, age, pubertal stage, ethnic group, genetic admixture, socio-economic status, and total energy intake. Our findings indicate a positive, significant association between the LP allele and body mass index ( p = 0.034), fat mass index (FMI) ( p = 0.043), and waist circumference ( p = 0.008), with associations being stronger in males than in females. Our results also reveal that lactose consumption is positively and nearly significantly associated with FMI.
- Publication
Genes & Nutrition, 2013, Vol 8, Issue 5, p487
- ISSN
1555-8932
- Publication type
Article
- DOI
10.1007/s12263-013-0335-9