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- Title
Cognitive function in a traumatic brain injury hyperbaric oxygen randomized trial.
- Authors
Richards, Michael F.; Kabban, Christine M. Schubert; Baugh, Laura M.; Prye, Jennifer; Wolf, E. George
- Abstract
Objective: Determine changes in cognition and posttraumatic stress disorder (PTSD) symptoms in subjects with traumatic brain injury (TBI) exposed to 2.4 atmospheres absolute (atm abs) breathing 100% oxygen vs. sham (1.3 atm-abs air). Methods: Fifty randomized subjects completed a total of 30 exposures. A concussion history was taken, then baseline, post-series, and six-week follow-up immediate post-concussion assessment and cognitive testing, Braincheckers and PTSD Checklist for Military (PCL-M) tests were administered. Results: No statistically significant differences between groups were noted, but both groups improved. Subgroups analyses, based on concussion history and individual. Conclusion: There was no statistically significant difference between a sham and 2.4 atm abs hyperbaric oxygen (HBO2) in cognitive scores from ImPACT and Braincheckers or composite scores in the PCL-M; however both groups showed improvement. Subgroups with favorable response to treatment are identified. Future studies evaluating HBO2 should consider concussion histories or focus on validating subgroup response to determine HBO2 as a potential adjunctive treatment for persistent symptoms following TBI.
- Subjects
BRAIN injuries; POST-traumatic stress disorder; TREATMENT of post-traumatic stress disorder; BRAIN concussion; COGNITIVE testing
- Publication
Undersea & Hyperbaric Medicine, 2015, Vol 42, Issue 4, p313
- ISSN
1066-2936
- Publication type
Article