We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Immunological regulation of metabolismma--novel quintessential role for the immune system in health and disease.
- Authors
Schaefer, Jeremy S.; Klein, John R.
- Abstract
The hypothalamus-pituitary-thyroid (HPT axis is an integrated hormone network that is essential for maintaining metabolic homeostasis. It has long been known that thyroid stimulating hormone (TSH), a central component of the HPT axis, can be made by cells of the immune system; however, the role of immune system TSH remains enigmatic and most studies have viewed it as a cytokine used to regulate immune function. Recent studies now indicate that immune system-derived TSH, in particular, a splice variant of TSH[3 that is preferentially made by cells of the immune system, is produced by a subset of hematopoietic cells that traffic to the thyroid. On the basis of these and other findings, we propose the novel hypothesis that the immune system is an active participant in the regulation of basal metabolism. We further speculate that this process plays a critical role during acute and chronic infections and that it contributes to a wide range of chronic inflammatory conditions with links to thyroid dysregulation. This hypothesis, which is amenable to empirical analysis, defines a previously unknown role for the immune system in health and disease, and it provides a dynamic connection between immune- endocrine interactions at the organismic level.
- Subjects
HYPOTHALAMIC-pituitary-adrenal axis; HOMEOSTASIS; THYROTROPIN; IMMUNE system; CYTOKINES
- Publication
FASEB Journal, 2011, Vol 25, Issue 1, p29
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.10-168203