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- Title
Prevention of diabetes in NOD mice by injection of autoreactive T-lymphocytes.
- Authors
Reich, Eva-Pia; Scaringe, Denise; Yagi, Junji; Sherwin, Robert S.; Janeway Jr., Charles A.; Reich, E P; Scaringe, D; Yagi, J; Sherwin, R S; Janeway, C A Jr
- Abstract
The nonobese diabetic (NOD) mouse develops a high incidence of autoimmune diabetes and is believed to be a good model for insulin-dependent diabetes mellitus (IDDM) in humans. We isolated T-lymphocyte lines from islets of newly diabetic NOD mice, some of which are autoreactive to NOD spleen cells. Because autoreactive T-lymphocytes have been implicated in immune suppression, we injected NOD mice with an autoreactive T-lymphocyte line. The injected mice had a marked decrease in incidence of IDDM compared with control mice. Moreover, their islets showed no insulitis at 1 yr of age. We conclude that autoreactive T-lymphocytes can prevent the development of IDDM in NOD mice. This result suggests that 1) islets contain both effector cells capable of damaging pancreatic beta-cells and cells able to regulate this autoimmune response, and 2) development of IDDM depends on the balance between these opposing forces.
- Publication
Diabetes, 1989, Vol 38, Issue 12, p1647
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.38.12.1647