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- Title
Diet-induced type II diabetes in C57BL/6J mice.
- Authors
Surwit, Richard S.; Kuhn, Cynthia M; Cochrane, Christina; Mccubbin, James A.; Feinglos, Mark N.; Surwit, R S; Kuhn, C M; Cochrane, C; McCubbin, J A; Feinglos, M N
- Abstract
We investigated the effects of diet-induced obesity on glucose metabolism in two strains of mice, C57BL/6J and A/J. Twenty animals from each strain received ad libitum exposure to a high-fat high-simple-carbohydrate diet or standard Purina Rodent Chow for 6 mo. Exposure to the high-fat, high-simple-carbohydrate, low-fiber diet produced obesity in both A/J and C57BL/6J mice. Whereas obesity was associated with only moderate glucose intolerance and insulin resistance in A/J mice, obese C57BL/6J mice showed clear-cut diabetes with fasting blood glucose levels of greater than 240 mg/dl and blood insulin levels of greater than 150 microU/ml. C57BL/6J mice showed larger glycemic responses to stress and epinephrine in the lean state than AJ mice, and these responses were exaggerated by obesity. These data suggest that the C57BL/6J mouse carries a genetic predisposition to develop non-insulin-dependent (type II) diabetes. Furthermore, altered glycemic response to adrenergic stimulation may be a biologic marker for this genetic predisposition to develop type II diabetes.
- Publication
Diabetes, 1988, Vol 37, Issue 9, p1163
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.37.9.1163