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- Title
Extract of Zanthoxylum bungeanum Maxim Seed Oil Reduces Hyperlipidemia in Hamsters Fed High-Fat Diet via Activation of Peroxisome Proliferator-Activated Receptor y.
- Authors
Gang Chen; Xue Gao; Kong-Shu Zhen; Zhong-Yi Yin; Xu-Xu Zheng
- Abstract
Purpose: To investigate the anti-hyperlipidaemic effect of extract of Zanthoxylum bungeanum Maxim. seed oil (EZSO) on high-fat diet (HFD)-induced hyperlipidemic hamsters. Methods: Following feeding with HFD for 30 days, hyperlipidemic hamsters were intragastrically treated with EZSO for 60 days. Serum levels of triglyceride (TG), total cholesterol (TC), low-density-lipoprotein-cholesterol (LDL-C), nitric oxide (NO) and malondialdehyde (MDA) were analyzed. Protein expression and location of peroxisome proliferator-activated receptor Y (PPARY) in liver were determined by Western blot and immunohistochemical assays, respectively. Results: EZSO at 5 and 10 g/kg significantly reduced levels of TG by 26 and 23% (p < 0.05), TC by 19% (p < 0.01) and 13% (p < 0.01), LDL-C by 18% (p < 0.05) and 21% (p < 0.01), NO by 15% (p < 0.01) and 31% (p < 0.01), and MDA by 16% (p < 0.05) and 30% (p < 0.01), respectively, in serum of hyperlipidemic hamsters. However, EZSO did not show significant effect on HDL-C level in serum. Furthermore, EZSO at 5 and 10 g/kg markedly promoted protein expression of PPARY by 71% (p < 0.05) and 102% (p < 0.01) in liver tissue of hyperlipidemic hamsters. EZSO also notably increased the content of PPARY protein in the nucleus of liver cells of hyperlipidemic hamsters. Conclusion: These findings suggest that EZSO can reduce hyperlipidemia and improve oxidative stress in hyperlipidemic hamsters through activation of PPARY, and that EZSO is a promising novel hypolipidemic health product.
- Subjects
THERAPEUTIC use of zanthoxylum; PHARMACODYNAMICS; HIGH-fat diet; PROTEIN expression; HYPERLIPIDEMIA treatment; PEROXISOME proliferator-activated receptors; HAMSTERS as laboratory animals
- Publication
Tropical Journal of Pharmaceutical Research, 2014, Vol 13, Issue 11, p1837
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v13i11.10