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- Title
Serum Follicular Fluid Growth Differentiation Factor 9 (GDF-9) and Bone Morphogenic Protein 15 (BMP-15) as Markers of Ovarian Reserve.
- Authors
Hassan, Muhjah Falah; Abdulhameed, Wasan Adnan
- Abstract
Background: Growth differentiation factor (GDF-9) and bone morphogenic protein (BMP-15) (GDF-9 co-factor) are proteins that are released by oocytes and control key stages of follicular development and growth. Objectives: To determine the ability of serum follicular fluid GDF-9 and BMP-15 in predicting ovarian reserve represented by their correlations with female age, traditional markers; antral follicle count (AFC) and anti-mullerian hormone (AMH). Materials and methods: In this prospective cohort study, 114 infertile females from the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Baghdad, Iraq, were included. Their age was 18–43 years old and their body mass index (BMI) was 19–30 Kg/m² . All were assessed on the second day of the menstrual cycle. Serum was taken to measure GDF-9 and BMP-15 using a special Kit by ELISA. Following oocyte retrieval, follicular fluid was collected for measuring GDF-9 and BMP-15. Results: The serum and follicular fluid GDF-9 and BMP-15 showed a significant correlation with the age of the patient, while there was no such association with AMH. Significant positive correlations were found between serum and follicular fluid GDF-9 and AFC, while only follicular fluid GDF-9 exhibited a significant positive correlation with mature II (MII) oocytes number. While, significant positive correlations were found between follicular fluid BMP-15 and the total number of oocytes. Conclusion: Serum follicular fluid GDF-9 and BMP-15 can be good predictors of ovarian reserve due to their significant negative correlations with age (oocyte quality) and significant positive correlations with AFC (quantity). Follicular fluid GDF-9, serum and follicular fluid BMP-15 can predict oocyte maturity.
- Subjects
OVARIAN reserve; GROWTH differentiation factors; BONE morphogenetic proteins; MENSTRUAL cycle; REPRODUCTIVE technology
- Publication
Al-Anbar Medical Journal, 2024, Vol 20, Issue 1, p25
- ISSN
2070-8882
- Publication type
Article
- DOI
10.33091/amj.2023.141993.1283