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- Title
Inhibition of Amyloid Fibril Growth and Dissolution of Amyloid Fibrils by Curcumin-Gold Nanoparticles.
- Authors
Palmal, Sharbari; Maity, Amit Ranjan; Singh, Brijesh Kumar; Basu, Sreetama; Jana, Nihar R.; Jana, Nikhil R.
- Abstract
Inhibition of amyloid fibrillation and clearance of amyloid fibrils/plaques are essential for the prevention and treatment of various neurodegenerative disorders involving protein aggregation. Herein, we report curcumin-functionalized gold nanoparticles (Au-curcumin) of hydrodynamic diameter 10-25 nm, which serve to inhibit amyloid fibrillation and disintegrate/dissolve amyloid fibrils. In nanoparticle form, curcumin is water-soluble and can efficiently interact with amyloid protein/peptide, offering enhanced performance in inhibiting amyloid fibrillation and dissolving amyloid fibrils. Our results imply that nanoparticle-based artificial molecular chaperones may offer a promising therapeutic approach to combat neurodegenerative disease.
- Subjects
AMYLOID beta-protein; CURCUMIN; GOLD nanoparticles; NEURODEGENERATION; PEPTIDES; MOLECULAR chaperones
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 20, p6184
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201400079