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- Title
FeCl<sub>3</sub>-Mediated Three-Component Cascade Reaction: An Effective Approach to the Construction of Highly Functionalized Pyrrolo[1,2- c]quinazolinones.
- Authors
Zheng, Hu ‐ Fei; Yu, Zhi ‐ Hua; Yuan, Wei; Tang, Zi ‐ Long; Clough, John; Gu, Yu ‐ Cheng; Shi, De ‐ Qing
- Abstract
An unexpected FeCl3-mediated three-component cascade reaction has been used to construct structurally diverse pyrrolo[1,2- c]quinazolinone derivatives with potential biological activities. This method has advantages of mild conditions, simple work-up, as well as wide substrate scope, which makes it a powerful approach to the synthesis of diverse pyrrolo[1,2- c]quinazolinones. This cascade reaction involves 1,3-dipolar cycloaddition between azomethine ylides and allenoates, followed by intramolecular nucleophilic addition in the presence of FeCl3. The obtained products could be easily transformed into derivatives with the pyrrolo[2,3- c]quinazoline alkaloid skeleton.
- Subjects
PQQ (Biochemistry); CHEMICAL derivatives; CHEMICAL synthesis; RING formation (Chemistry); YLIDES; SCHIFF bases
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 6, p1711
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201304028