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- Title
Harmless glucose‐modified ruthenium complexes suppressing cell migration of highly invasive cancer cell lines.
- Authors
Lamač, Martin; Horáček, Michal; Červenková Šťastná, Lucie; Karban, Jindřich; Sommerová, Lucia; Skoupilová, Hana; Hrstka, Roman; Pinkas, Jiří
- Abstract
Glucose‐substituted ruthenium complexes [(η6‐benzyl‐glucose)RuCp*]+Cl−, where Cp* = η5‐C5Me5; benzyl‐glucose = peracetylated benzyl β‐d‐glucopyranoside (1), benzyl β‐d‐glucopyranoside (2), have been prepared and used as efficient antimigration and anti‐invasive agents against metastatic breast cancer cells (MDA‐MB‐231) and cisplatin‐resistant ovarian cancer cells (SK‐OV‐3). In addition, these complexes were found to be essentially non‐toxic against non‐cancerous human kidney cells (HEK293).
- Subjects
CELL migration; CANCER cells; RUTHENIUM; CELL lines; METASTATIC breast cancer; CANCER cell migration
- Publication
Applied Organometallic Chemistry, 2020, Vol 34, Issue 1, pN.PAG
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.5318