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- Title
Interleukin-11 receptor alpha is expressed on canine osteosarcoma.
- Authors
Sottnik, J. L.; Thamm, D. H.
- Abstract
Osteosarcoma (OSA) is the most common bone tumour in humans and companion animals, and has a poor long-term prognosis. The identification of new markers and targeted therapies may help increase long-term survival of these patients. Previous studies have demonstrated that interleukin-11 receptor alpha (IL-11Rα) is expressed in human and murine OSA but not in normal bone. The current study demonstrated via western analysis, immunoflourescence and immunohistochemistry that IL-11Rα was expressed in primary canine OSA tissues as well as in a number of canine OSA cell lines, but not in normal canine bone. Cytotoxin-conjugated antibodies targeting IL-11Rα-mediated canine OSA cytotoxicity. Thus, canine OSA may be a valuable model for the evaluation of IL-11Rα directed therapies.
- Subjects
OSTEOSARCOMA; CELL culture; CELL lines; BONE cancer; INTERLEUKINS
- Publication
Veterinary & Comparative Oncology, 2010, Vol 8, Issue 2, p96
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/j.1476-5829.2010.00209.x