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- Title
Cyclooxygenase-2 (COX-2) expression in canine intracranial meningiomas.
- Authors
Rossmeisl, J. H.; Robertson, J. L.; Zimmerman, K. L.; Higgins, M. A.; Geiger, D. A.
- Abstract
Meningiomas are the most common canine intracranial tumour. Neurologic disability and death from treatment failure remain problematic despite current surgical and radiotheraputic treatments for canine intracranial meningiomas. Cyclooxygenase-2 (COX-2) over-expression has been demonstrated in multiple canine malignancies, and COX-2 inhibitory treatment strategies have been shown to have both preventative and therapeutic effects in spontaneous and experimental models of cancer. The purpose of this study was to evaluate COX-2 expression in canine intracranial meningiomas. Immunohistochemical and Western blot (WB) analyses showed COX-2 expression in multiple tissues of the normal canine brain, and 87% (21/24) of intracranial meningiomas studied were immunoreactive to COX-2. No significant associations between COX-2 immunoreactivity and tumour grade were identified. Further studies are required to elucidate the physiologic roles of constitutive COX-2 expression in the central nervous system as well as its participation in meningioma tumourigenesis.
- Subjects
CYCLOOXYGENASE 2; DOG diseases; MENINGIOMA; BRAIN tumors; WESTERN immunoblotting; IMMUNOHISTOCHEMISTRY; VETERINARY oncology; VETERINARY medicine
- Publication
Veterinary & Comparative Oncology, 2009, Vol 7, Issue 3, p173
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/j.1476-5829.2009.00188.x