We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hyperbaric oxygenation pretreatment induces catalase and reduces infarct size in ischemic rat myocardium.
- Authors
Chan-Hyung Kim; Hong Choi; Yang-Sook Chun; Gi-Tae Kim; Jong-Wan Park; Myung-Suk Kim
- Abstract
Ischemia-reperfusion injury is a major complication occurring in heart stroke, cardiopulmonary bypass surgeries, and heart transplantation. Reactive oxygen species generated during the reperfusion phase overwhelm the scavenging capacities of antioxidant enzymes, and result in oxidative damage to the myocardium. We examined whether hyperbaric oxygenation (HBO) pretreatment induces antioxidant enzymes and protects the heart from subsequent ischemia-reperfusion injury. Rats were intermittently exposed to 100% O2 at 3 ATA (where ATA is absolute atmosphere) for 1 h daily and then sacrificed after 24 h of recovery in room air. Isolated hearts were subjected to 40 min of ischemia and 90 min of reperfusion. HBO pretreatment was found to condition the heart and enhance enzymatic activity and gene expression of catalase, thereby significantly reducing infarct size after reperfusion. A catalase inhibitor, 3-amino-1,2,4-triazole, completely abolished the infarct-limiting effect of HBO pretreatment, which suggests that HBO-induced tolerance against ischemia-reperfusion injury is due to catalase induction. Our results imply that HBO preconditioning may be developed as a new preventive measure for reperfusion injury in the heart.
- Subjects
HYPERBARIC oxygenation; OXYGEN therapy; COMPRESSED air; ISCHEMIA; CARDIAC surgery; REPERFUSION injury
- Publication
Pflügers Archiv: European Journal of Physiology, 2001, Vol 442, Issue 4, p519
- ISSN
0031-6768
- Publication type
Article
- DOI
10.1007/s004240100571