We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis and Biological Studies on Dinuclear Gold(I) Complexes with Di-(N-Heterocyclic Carbene) Ligands Functionalized with Carbohydrates.
- Authors
Tresin, Federica; Stoppa, Valentina; Baron, Marco; Biffis, Andrea; Annunziata, Alfonso; D'Elia, Luigi; Monti, Daria Maria; Ruffo, Francesco; Roverso, Marco; Sgarbossa, Paolo; Bogialli, Sara; Tubaro, Cristina; Szostak, Michal
- Abstract
The design of novel metal complexes with N-heterocyclic carbene (NHC) ligands that display biological activity is an active research field in organometallic chemistry. One of the possible approaches consists of the use of NHC ligands functionalized with a carbohydrate moiety. Two novel Au(I)–Au(I) dinuclear complexes were synthesized; they present a neutral structure with one bridging diNHC ligand, having one or both heterocyclic rings decorated with a carbohydrate functionality. With the symmetric diNHC ligand, the dicationic dinuclear complex bearing two bridging diNHC ligands was also synthesized. The study was completed by analyzing the antiproliferative properties of these complexes, which were compared to the activity displayed by similar mononuclear Au(I) complexes and by the analogous bimetallic Au(I)–Au(I) complex not functionalized with carbohydrates.
- Subjects
BIOSYNTHESIS; BRIDGING ligands; LIGANDS (Biochemistry); CARBOHYDRATES; CARBENE synthesis; ORGANOMETALLIC chemistry; CARBENES
- Publication
Molecules, 2020, Vol 25, Issue 17, p3850
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25173850