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- Title
Synthesis, X-ray Analysis, Biological Evaluation and Molecular Docking Study of New Thiazoline Derivatives.
- Authors
Mabkhot, Yahia N.; Algarni, H.; Alsayari, Abdulrhman; Bin Muhsinah, Abdullatif; Kheder, Nabila A.; Almarhoon, Zainab M.; Al-aizari, Faiz A.
- Abstract
A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing 1H-NMR, 13C-NMR, X-ray and MS techniques. The in vitro antitumor activities were assessed against human hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT-116) cell lines. The results revealed that the thiazolines 5b and 2c exhibited significant activity against the two cell lines. The in vitro antimicrobial screening showed that the thiazolines 2c, 5b and 5d showed promising inhibition activity against Salmonella sp. Additionally, the inhibition activity of thiazolines 2e and 5b against Escherichia coli was comparable to that of the reference compound gentamycin.
- Subjects
MOLECULAR docking; THIAZOLINES; LIVER cancer; COLON cancer; ESCHERICHIA coli; NUCLEAR magnetic resonance
- Publication
Molecules, 2019, Vol 24, Issue 9, p1654
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24091654