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- Title
Terretonin N: A New Meroterpenoid from Nocardiopsis sp.
- Authors
Hamed, Abdelaaty; Abdel-Razek, Ahmed S.; Frese, Marcel; Stammler, Hans Georg; El-Haddad, Atef F.; Ibrahim, Tarek M. A.; Sewald, Norbert; Shaaban, Mohamed
- Abstract
Terretonin N (1), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of a solid-state fermented culture of Nocardiopsis sp. Their structures were elucidated by spectroscopic analysis. The structure and absolute configuration of 1 were unambiguously determined by X-ray crystallography. The isolation and taxonomic characterization of Nocardiopsis sp. is reported. The antimicrobial activity and cytotoxicity of the strain extract and compound 1 were studied using different microorganisms and a cervix carcinoma cell line, respectively.
- Subjects
SOLID-state fermentation; ANTI-infective agents; MICROORGANISMS; CERVICAL cancer treatment; ETHYL acetate; X-ray crystallography
- Publication
Molecules, 2018, Vol 23, Issue 2, p299
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23020299