We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Labdane-Type Diterpenes, Galangalditerpenes A-C, with Melanogenesis Inhibitory Activity from the Fruit of Alpinia galanga.
- Authors
Yoshiaki Manse; Kiyofumi Ninomiya; Ryosuke Nishi; Yoshinori Hashimoto; Chaipech, Saowanee; Osamu Muraoka; Toshio Morikawa
- Abstract
In our continuing study of biologically active natural products from the fruit of Alpinia galanga (Zingiberaceae), we newly isolated three new labdane-type diterpenes, termed galangalditerpenes A-C (1-3), along with four known sesquiterpenes (4-7) and two diterpenes (8 and 9). The stereostructures of 1-3 were elucidated on the basis of their spectroscopic properties. The melanogenesis inhibitory activities in theophylline-stimulated murine B16 melanoma 4A5 cells of these isolates, including the new diterpenes (1-3, IC50 = 4.4, 8.6, and 4.6 μM, respectively), were found to be more than 6-87-fold higher than that of arbutin (174 μM), a commercially available positive control.
- Subjects
BIOACTIVE compounds; ALPINIA; LABDANES; DITERPENES; MELANOGENESIS; SESQUITERPENES
- Publication
Molecules, 2017, Vol 22, Issue 12, p2279
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22122279