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- Title
Conjugates of 1′-Aminoferrocene-1-carboxylic Acid and Proline: Synthesis, Conformational Analysis and Biological Evaluation.
- Authors
Kovačević, Monika; Molčanov, Krešimir; Radošević, Kristina; Gaurina Srček, Višnja; Roca, Sunčica; Čače, Alan; Barišić, Lidija
- Abstract
Our previous studies showed that alteration of dipeptides Y-Fca-Ala-OMe (III) into Y-Ala-Fca-OMe (IV) (Y = Ac, Boc; Fca = 1′-aminoferrocene-1-carboxylic acid) significantly influenced their conformational space. The novel bioconjugates Y-Fca-Pro-OMe (1, Y = Ac; 2, Y = Boc) and Y-Pro-Fca-OMe (3, Y = Boc; 4, Y = Ac) have been prepared in order to investigate the influence of proline, a well-known turn-inducer, on the conformational properties of small organometallic peptides with an exchanged constituent amino acid sequences. For this purpose, peptides 1-4 were subjected to detailed spectroscopic analysis (IR, NMR, CD spectroscopy) in solution. The conformation of peptide 3 in the solid state was determined. Furthermore, the ability of the prepared conjugates to inhibit the growth of estrogen receptor-responsive MCF-7 mammary carcinoma cells and HeLa cervical carcinoma cells was tested.
- Subjects
PROLINE; CONJUGATE acid-base pairs; PSYCHODIAGNOSTICS; CARBOXYLIC acids; MOLECULAR conformation
- Publication
Molecules, 2014, Vol 19, Issue 8, p12852
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules190812852