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- Title
Sesquiterpenes from the Brazilian Red Alga Laurencia dendroidea J. Agardh.
- Authors
da Silva Machado, Fernanda Lacerda; Biá Ventura, Thatiana Lopes; de Souza Gestinari, Lísia Mônica; Cassano, Valéria; Lamounier Camargos Resende, Jackson Antônio; Kaiser, Carlos Roland; Lasunskaia, Elena B.; Muzitano, Michelle Frazão; Soares, Angélica Ribeiro
- Abstract
Two new chamigrane sesquiterpenes 1-2 and three known compounds 3-5 were isolated from a lipophilic extract of the red alga Laurencia dendroidea collected from the Southeastern Brazilian coast. Dendroidone (1) and dendroidiol (2) were isolated from samples collected at Biscaia Inlet, Angra dos Reis, Rio de Janeiro and at Manguinhos Beach, Serra, Espírito Santo, respectively. Debromoelatol (3), obtusane (4) and (1S*,2S*,3S*,5S*,8S*,9S*)-2,3,5,9-tetramethyltricyclo[6.3.0.01.5]undecan-2-ol (5) were obtained from specimens collected at Vermelha Beach, Parati, Rio de Janeiro. The structures of new compounds were elucidated by extensive NMR (1H-, 13C-, COSY, HSQC, HMBC and NOESY) and high resolution mass spectrometry analysis. Additionally, the absolute configuration of compound 2 was assigned by X-ray analysis. Full spectroscopic data is described for the first time for compound 3. Anti-inflammatory and antimycobacterial activities of compounds 2-5 were evaluated. Compounds 3-5 inhibited the release of inflammatory mediator NO while TNF-α levels were only affected by 3. All compounds tested displayed moderate antimycobacterial action.
- Subjects
RIO de Janeiro (Brazil); LAURENCIA; SESQUITERPENES; LIPOPHILICITY; HYDROPHOBIC surfaces
- Publication
Molecules, 2014, Vol 19, Issue 3, p3181
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules19033181