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- Title
New Short Strategy for the Synthesis of the Dibenz[b,f]oxepin Scaffold.
- Authors
Moreno, David R. R.; Giorgi, Giorgio; Salas, Cristian O.; Tapia, Ricardo A.
- Abstract
In this report a short and efficient synthesis of the dibenz[b,f]oxepin framework through intramolecular SNAr and McMurry reactions is described. The diaryl ethers required for the McMurry reaction have been obtained in good yields under microwave-assisted conditions of the reaction of salicylaldehydes with fluorobenzaldehydes without catalysts. Application of an intramolecular McMurry reaction to the synthesized diarylethers using TiCl4/Zn in THF gave the target dibenzo[b,f]oxepin system in 53%-55% yields.
- Subjects
CHEMICAL inhibitors; CHEMICALS; ALLOXAZINE; ANTIFREEZE solutions; ANTIOXIDANTS
- Publication
Molecules, 2013, Vol 18, Issue 12, p14797
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules181214797