We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A General Synthetic Procedure for 2-chloromethyl-4(3H)-quinazolinone Derivatives and Their Utilization in the Preparation of Novel Anticancer Agents with 4-Anilinoquinazoline Scaffolds.
- Authors
Hong-Ze Li; Hai-Yun He; Yuan-Yuan Han; Xin Gu; Lin He; Qing-Rong Qi; Ying-Lan Zhao; Li Yang
- Abstract
In our ongoing research on novel anticancer agents with 4-anilinoquinazoline scaffolds, a series of novel 2-chloromethyl-4(3H)-quinazolinones were needed as key intermediates. An improved one-step synthesis of 2-chloromethyl-4(3H)-quinazolinones utilizing o-anthranilic acids as starting materials was described. Based on it, 2-hydroxymethyl- 4(3H)-quinazolinones were conveniently prepared in one pot. Moreover, two novel 4-anilinoquinazoline derivatives substituted with chloromethyl groups at the 2-position were synthesized and showed promising anticancer activity in vitro.
- Subjects
ANTINEOPLASTIC agents; CHLOROMETHYL group; TISSUE scaffolds; CANCER treatment; MATRIX derivatives
- Publication
Molecules, 2010, Vol 15, Issue 12, p9473
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules15129473