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- Title
Relationship of p53 and Vascular Endothelial Growth Factor Expression to Clinicopathological Factors in Human Scirrhous Gastric Cancer.
- Authors
Baba, M.; Konno, H.; Maruo, Y.; Tanaka, T.; Kanai, T.; Matsumoto, K.; Matsuura, M.; Nishino, N.; Maruyama, K.; Nakamura, S.; Baba, S.
- Abstract
Although scirrhous cancer has the highest malignant potential among various types of gastric cancer, its pathogenesis is still unclear. The relationship between expression of p53 or vascular endothelial growth factor (VEGF) and clinicopathological variables was investigated by immunohistochemical analysis of archival specimens from 40 patients with scirrhous gastric cancer. Staining for p53 and VEGF was observed in the nuclei and cytoplasm of the tumor cells, respectively. There was no significant association between expression of p53 or VEGF and sex, age, depth of invasion, lymph node metastasis or histological stage. Peritoneal dissemination was the most frequent mode of recurrence, and the depth of tumor invasion was a crucial factor. The recurrence rate was 83.9% (26/32) in patients with serosal invasion, whereas it was 22.2% (2/9) in patients without serosal invasion. Only 7 out of 40 patients (17.5%) survived without recurrence. Among them, the VEGF-positive rate was 14.3% (1/7), whereas it was 52.6% (10/19) in the patients with recurrence. There was no correlation between p53 and VEGF staining. These findings suggest that the progression of scirrhous gastric cancer may be promoted by VEGF overexpression, which is not upregulated by p53 mutation.
- Subjects
P53 antioncogene; VASCULAR endothelium; GROWTH factors; STOMACH cancer; CYTOPLASM; CLINICAL pathology
- Publication
European Surgical Research, 1998, Vol 30, Issue 2, p130
- ISSN
0014-312X
- Publication type
Article
- DOI
10.1159/000008568