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- Title
Commentary on "Real time ultrasound derived fat fraction in pediatric population: Feasibility validation with MR-PDFF".
- Authors
Dillman, Jonathan R.
- Abstract
The prevalence of non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) in children is increasing globally. A recent study published in Pediatric Radiology has demonstrated the use of a novel technology, ultrasound-derived fat fraction (UDFF), to detect and measure hepatic steatosis in children. The study showed that UDFF measurements positively correlate with MRI-proton density fat fraction (PDFF), the current clinical reference standard for noninvasive diagnosis and staging of hepatic steatosis. UDFF has the potential to be a valuable noninvasive diagnostic tool for evaluating children with known or suspected NAFLD/NASH, and it may also be a lower cost and better tolerated alternative to MRI and biopsy for clinical trials. However, further research is needed to confirm these findings and evaluate the repeatability and dynamic nature of UDFF measurements.
- Subjects
NON-alcoholic fatty liver disease; CHILD patients; NONINVASIVE diagnostic tests; FATTY liver; FAT; ULTRASONIC imaging
- Publication
Pediatric Radiology, 2023, Vol 53, Issue 12, p2476
- ISSN
0301-0449
- Publication type
Article
- DOI
10.1007/s00247-023-05755-x