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- Title
Experimental Evaluation of Anxiolytic and Analgesic Properties of a New Linear Methoxyphenyltriazaalkane Derivative with Cardiotropic Activity.
- Authors
Kolik, L. G.; Nadorova, A. V.; Tsorin, I. B.; Barchukov, V. V.; Mokrov, G. V.; Likhosherstov, A. M.; Gudasheva, T. A.; Kryzhanovskii, S. A.; Durnev, A. D.
- Abstract
The anxiolytic and analgesic properties of compound ALM-802, a cardiotropic linear methoxyphenyltriazaalkane derivative, combining pharmacophore elements of p-FOX inhibitors trimetazidine and ranolazine were studied in vivo. In the elevated plus-maze test, ALM-802 after acute intraperitoneal administration in doses of 1-8 mg/kg dose-dependently prevented the development of anxiety in BALB/c mice. Chronic intraperitoneal administration of ALM-802 in a dose of 2 mg/kg to alcohol-preferring rats attenuated anxiogenesis induced by ethanol withdrawal. ALM-802 demonstrated antinociceptive activity in C57BL/6 mice during thermal stimulation of nociceptors in the hot plate test and during modeling of visceral pain in the acetic acid writhing test. Thus, ALM-802 exhibits anxiolytic and analgesic properties in the dose range corresponding to its anti-ischemic and antiarrhythmic effects.
- Subjects
VISCERAL pain; LABORATORY mice; ACETIC acid; TRIMETAZIDINE; NOCICEPTORS
- Publication
Bulletin of Experimental Biology & Medicine, 2021, Vol 170, Issue 6, p763
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-021-05149-9