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- Title
Human Diploid Fibroblast Cell Lines — a Model System for Studying Immunodulatory Properties of Modern Immunobiological Drugs and Viruses.
- Authors
Konyuschko, O. I.; Ozherelkov, S. V.; Vorovich, M. F.; Ivanova, A. L.; Sotskova, S. E.; Ishmuhametov, A. A.; Kozhevnikova, T. N.; Sanin, A. V.
- Abstract
The immunomodulatory properties of immunobiological drugs Glutoxim and Phosprenyl we well as vesicular stomatitis virus and inactivated tick-borne encephalitis vaccine virus were studied using human diploid fibroblast cell line from the collection of M. P. Chumakov Federal Research Center for Research and Development of Immunobiological Products. All tested preparations exhibited immunomodulatory activity in human diploid fibroblast cell line. Glutoxim in doses of 0.1 and 0.25 μg/ml stimulated production of IL-6 and IL-10 during 24-48 h of culturing, but did not stimulate production of IL-1β. Phosprenyl, on the contrary, increased production of IL-1β and the levels of IL-6 and IL-10. Vesicular stomatitis virus stimulated the production of IL-1β, IL-6, and IL-10, while inactivated tick-borne encephalitis vaccine virus stimulated the production of cytokines IL-8 and IL-18. Immunomodulatory activity of inactivated tick-borne encephalitis vaccine virus was first demonstrated in the in vitro system.
- Subjects
TICK-borne encephalitis viruses; CELL lines; VESICULAR stomatitis; INTERLEUKIN-6; CASTOR bean tick; VIRUSES; VIRUS inactivation
- Publication
Bulletin of Experimental Biology & Medicine, 2020, Vol 170, Issue 2, p219
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-020-05037-8