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- Title
Efficiency of Various Vitamin Doses for Polyhypovitaminosis Correction in Rats.
- Authors
Kodentsova, V.; Vrzhesinskaya, O.; Beketova, N.; Kosheleva, O.; Sokol'nikov, A.
- Abstract
A 5-fold decrease of the content of vitamin mixture in the ration and exclusion of vitamin E from this mixture over 4 weeks led to a significant growth delay in rats initially weighing 58.1±0.5 g, but was inessential for the growth rates of animals weighing 107.1±1.1 g. The decrease in the levels of vitamins A and B in the liver and of 25-hydroxyvitamin D in the plasma of younger rats was more significant, this indicating their higher sensitivity to alimentary vitamin deficit. The increase in vitamin content in the ration to 100% over 5 days led to a significant body weight increment but did not restore vitamin levels in the liver, restoring, however, plasma levels of vitamins E and 25-hydroxyvitamin D. Addition of 50% vitamin content of the vitamin mixture for controls to vitamin-deficient rations of older rats for 2 weeks improved the levels of vitamins B and B, but was virtually inessential for the liver content of vitamins A and E. High dose (158-200%) vitamins in animals of both age groups repaired the deficit of all vitamins, except vitamin A, despite the fact that its doses were the highest. These results validate long-term vitamin consumption for repair of their deficit.
- Subjects
RATS; VITAMIN D; CONSUMPTION (Economics); ALIMENTARY canal; ANIMALS
- Publication
Bulletin of Experimental Biology & Medicine, 2014, Vol 157, Issue 5, p608
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-014-2626-6