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- Title
Epigenetic regulation of chromatin structure and gene function by biotin: are biotin requirements being met?
- Authors
Zempleni, Janos; Chew, Yap Ching; Hassan, Yousef I.; Wijeratne, Subhashinee S. K.
- Abstract
The article presents the study on the epigenetic regulation of chromatin structure and gene function of biotin. Deoxyribonucleic acid (DNA) and DNA-binding proteins composes chromatin which includes histones and non-histone proteins. There have been five major classes of histones identified in mammals including H1, H2A, H2B, H3, and H4. These histones consist of a global domain and flexible amino terminus. Mass spectrometry (MS) is used to extract histones from human lymphoid cells to confirm biotinylation sites.
- Subjects
CHROMATIN; BIOTIN; MASS spectrometry; DNA-binding proteins; HISTONES; NONHISTONE chromosomal proteins; NUCLEOPROTEINS; MAMMALS; LYMPHOID tissue
- Publication
Nutrition Reviews, 2008, Vol 66, pS46
- ISSN
0029-6643
- Publication type
Article
- DOI
10.1111/j.1753-4887.2008.00073.x