We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1.
- Authors
Zhang, Jianke; Cado, Dragana; Chen, Ann; Kabra, Nisha H.; Winoto, Astar
- Abstract
Presents research which studied the role of FADD in vivo by generating FADD-deficient mice. Role of apoptosis in the immune system; Role of Fas in apoptosis and lymphocyte homeostasis; What FADD/Mort1 is and its relation to apoptosis; Methods; No redundant Fas apoptotic pathways; Impairment of activation-induced proliferation; Unexpected tie between cell proliferation and apoptosis.
- Subjects
APOPTOSIS; T cells; CELL proliferation -- Molecular aspects; MAMMAL growth; IMMUNOLOGY; MORT1 protein
- Publication
Nature, 1998, Vol 392, Issue 6673, p296
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/32681