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- Title
Effect of Water T2 Shortening in the Quantification of in-vitro Proton MR Spectroscopy.
- Authors
Hernández‐Tamames, Juan Antonio; Mato Abad, Virginia; García‐Álvarez, Roberto; González‐Zabaleta, Javier; Pereira Loureiro, Javier; Álvarez‐Linera, Juan
- Abstract
<bold>Purpose: </bold>This work studies the relationship between in-vitro Proton Magnetic Resonance Spectroscopy metabolite quantification and water T2 decay. <bold>Materials and Methods: </bold>An in-vitro correspondence is established between the iron accumulation and the shortening of water T2 relaxation times using seven spherical phantoms, 6 of them were doped with an increasing concentration of iron metal nanoparticles solution. This is later proposed as a source of error during the LCModel metabolite quantification of either absolute concentrations or ratios. <bold>Results: </bold>The Pearson's correlation coefficient between water T2 values against absolute metabolite concentrations was on average [r] = 0.97 and on average [r] = 0.85 for metabolite ratios. <bold>Conclusion: </bold>These results suggest that the shortening of T2 values should be taken into account when performing metabolite quantification. Also, the need of demonstrated similar results in in-vivo studies, since the presence of iron deposits or other factors affecting the water T2 decay measurements could explain part of the inter-subject variability in the metabolite concentration and ratio quantification.
- Subjects
PROTON magnetic resonance spectroscopy; NUCLEAR magnetic resonance spectroscopy; METABOLITES; IRON; BRAIN imaging; BRAIN metabolism; BRAIN; CHOLINE; MATHEMATICAL models; IMAGING phantoms; WATER in the body; THEORY; IN vitro studies
- Publication
Journal of Neuroimaging, 2016, Vol 26, Issue 1, p58
- ISSN
1051-2284
- Publication type
journal article
- DOI
10.1111/jon.12258